GI drugs: Rotation prep
- Simple Medicine
- Jul 13, 2022
- 1 min read

Brand names:
Histamine-2 blockers - Mild GERD, Peptic ulcer, gastritis
Ranitidine (Zantac Pro)
Famotidine (Pepcid)
Nizatidine (Axid AR)
Cimetidine (Tagamet HB). A/E: Antiandrogenic effects (prolactin release, gynecomastia, impotence), can cross BBB so cause confusion and headaches, can cross placenta. Also decreases renal excretion of creatinine.
Proton Pump inhibitors- peptic ulcer, Zollinger Ellison syndrome, Stress ulcer, H.Pylori
Omeprazole (Prilosec)
Aspirin and Omeprazole (Yosprala)
Lansoprazole (Prevacid)
Esomeprazole (Nexium)
Pantoprazole (Protonix)
Rabeprazole (Acip Hex)
Dexlansoprazole (Dexilent)
A/E: Increase risk of C diff infection, pneumonia, Acute interstitial nephritis, decreases Mg and calcium absorption (increasing risk of fracture in the elderly)
Loperamide (Imodium) - Diarrhea
mu-opioid receptor agonist that slows gut motility so can cause constipation.
Ondansetron (Zofran)- Vomitting
5-HT3 antagonist used in patients undergoing chemotherapy
A/E: Constipation, QT prolongation, serotonin syndrome
Metoclopramide (Reglan, Metozolv) - Diabetic and Post surgery gastroparesis, antiemetic, persistent GERD
D2 antagonist, promotes gastric emptying, increases LES tone, motility, contractility and resting tone.
A/E: increased parkinsonian effects, tardive dyskinesia, Restlessness, diarrhea, depression
C/I: in patients with small bowel obstruction or Parkinson disease
Misoprostol (Cytotec) - NSAID induced peptic ulcers and for induction of labor (can cause abortion)
PGE1 analog so it increases the secretion of gastric mucous barrier
A/E: Abortion, Diarrhea
Sulfasalazine (Azulfidine) - Crohn disease, Ulcerative Colitis
Sulfapyridine (anti-bacterial) and 5-aminosalicylic acid (5-ASA) (anti-inflammatory) combo.
A/E: reversible Oligospermia
Orlistat (Alli, Xenical) - Weight loss
Inhibits gastric and pancreatic lipase to decrease breakdown and absorption of dietary fats
A/E: Flatulence, Diarrhea, Smelly poop
Aprepitant (Emend) - Antiemetic for chemotherapy-induced nausea and vomiting.

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